Top 3 Injectable Psoriasis Treatments

Injectable treatments for psoriasis can be helpful when topical remedies fail. Topical anti-inflammatory creams and ointments are often prescribed as first lines of defense against psoriasis; they're cheaper, usually effective, and can be administered safely at home. Injectable medications require training from your doctor to use at home, and they are generally more effective in reducing skin plaques and other psoriasis symptoms. Has your doctor recommended injectable treatments for psoriasis? Read on and learn more about the top three injected treatment options that can help with psoriasis symptoms.

What are the top three injectable medications for psoriasis?

There are many injectable options to choose from, and people should talk to their doctors to find their best choices. That said, our top three treatments are Taltz (ixekizumab), Siliq (brodalumab), and Trexall (methotrexate).

How are these injectable medications different?

Taltz and Siliq are biologic treatments, which makes them different than Trexall, which is an antimetabolite. Your doctor can help you decide which type of medication is best for your condition. Cost may be a factor, as biologic medications can be significantly more expensive.

What should patients know about Trexall?

Injections of Trexall can be used in conjunction with other medications or as a single form of treatment. The shot can be given under the skin or into a muscle, and your doctor would show you the correct way to do this. Trexall injections are only needed once per week. It has been associated with side effects ranging from chest pain to fevers to seizures, but the more serious side effects are rare.

What should patients know about Siliq?

Siliq, which gained FDA approval in 2017 for use with psoriasis, is a biologic therapy that can be administered either via injection, by mouth or even with phototherapy. The most common side effects are fatigue, diarrhea, nausea, joint pain, muscle pain and other non-serious conditions. After taking injections once weekly for the first three weeks, the dosage requirement is one injection every two weeks going forward.

What should patients know about Taltz?

Taltz is a newer biologic treatment for psoriasis in which up to 90 percent of patients in clinical trials saw improvements in their symptoms. Patients begin with two same-day starter injections, followed by just one injection every two weeks for three months. After that, the dosage is just one injection every four weeks. Common side effects include skin site reactions, fungal infections nausea and respiratory infections. More serious side effects may develop.

What are biologic treatments?

Biologic medications are made from either living organisms or substances with similar properties. They stimulate the body's immune system to take actions against certain diseases. Numerous biologics can be used in the treatment of psoriasis.

What are antimetabolites?

Antimetabolites block the reproduction of cells by interfering with a key cellular metabolic process. They are used for the treatment of psoriasis, rheumatoid arthritis and even certain types of cancer.

Can injected treatments be combined with topical therapies?

In many cases, people with psoriasis can continue using their topical treatments even while receiving injected medications. This is important, considering the moisturizing and cleansing properties of many topical treatments.

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